On October 31, 2024 (the "Separation Date"), Kimi Iguchi and Sage Therapeutics, Inc. (the "Company") entered into a separation agreement (the "Iguchi Separation Agreement") providing for the resignation of Ms. Iguchi from her positions as the Chief Financial Officer and Treasurer of the Company and from any and all other positions she holds as an officer or employee of the Company or an officer, employee or director of any of its subsidiaries. As previously announced, Ms. Iguchi's departure from the Company was part of the October 2024 reorganization of the Company's business operations and reduction in the Company's workforce (the "Reorganization"). The Iguchi Separation Agreement also includes a release of claims by Ms. Iguchi and non-solicitation, non-disclosure and non-disparagement obligations following the Separation Date.